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Lambda Light Chain(SHL53),MMab
The basic structure of the immunoglobulin molecule consists of two identical heavy chains ( γ、μ、α、δ、ε) and two identical light chains (κorλ). Any heavy chain can be combined with a light chain, but the two light chains are of the same type on the immunoglobulin molecule. The ratio of the κ light chain and the λ light chain between the Ig and subunit is different. Additionally the ratio of the κ light chain and the λ light chain of B-cell is about 2:1 in the polyclonal groups.But a single B cell expresses only the κchain or the λ chain, and never expresses both.Usually most of the κ and λ chains bind to heavy-chain immunoglobulins. However, in normal individuals, there are low levels of free light chains in the serum. So,the presence of cells with a mixture of κchains and λ chains indicates the presence of polyclonal group and B-cell reactive or non-tumor proliferation.
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Staining Tissue
[As Figure shows]
Tonsil tissue stained with Lambda Light Chain λ
[Intended Use]
The basic structure of the immunoglobulin molecule consists of two identical heavy chains ( γ、μ、α、δ、ε) and two identical light chains (κorλ). Any heavy chain can be combined with a light chain, but the two light chains are of the same type on the immunoglobulin molecule. The ratio of the κ light chain and the λ light chain between the Ig and subunit is different. Additionally the ratio of the κ light chain and the λ light chain of B-cell is about 2:1 in the polyclonal groups.But a single B cell expresses only the κchain or the λ chain, and never expresses both.Usually most of the κ and λ chains bind to heavy-chain immunoglobulins. However, in normal individuals, there are low levels of free light chains in the serum. So,the presence of cells with a mixture of κchains and λ chains indicates the presence of polyclonal group and B-cell reactive or non-tumor proliferation.
[Specifications]
| Product Name | Lambda Light Chain(SHL53),MMab |
| Catalog No. | CLM-0010 |
| Intended Use | IVD, RUO |
| Species Reactivity | Human; others not tested |
| Cellular Localization | Cytoplasm / Nucleus |
| Antibody Type | Mouse Monoclonal |
| Clone | SHL53 |
| Format and Volume | Ready-to-use: 1mL, 3mL, 6mL Concentrated: 0.1mL, 0.2mL and 1mL |
[Datasheets & SDS]
| IVD Datasheet (IFU) | ↕️ Download |
| RUO Datasheet (IFU) | ↕️ Download |
| SDS sheet | check with sales |
[Storage and Validity]
Store at 2~8°C. Avoid freezing.
Maintain temperature below room temperature during transport, ensuring it does not exceed one week.
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