Alpha-1-antitrypsin is synthesized in the liver and is present in serum and tissue fluid as a protease inhibitor, especially as an elastase inhibitor.Its main function is to neutralize the release of elastase by neutrophils in the inflammatory response.The deficiency of Alpha-1-antitrypsin may lead to lung failure to inhibit tissue destruction induced by elastase. Alpha-1-antitrypsin deficiency is associated with acinar emphysema and liver disease.In the liver, deficiency of c-1-antitrypsin may cause neonatal hepatitis or cirrhosis of the liver in some individuals during adolescence or adulthood.
Tonsil tissue stained with AAT
Alpha-1-antitrypsin is synthesized in the liver and is present in serum and tissue fluid as a protease inhibitor, especially as an elastase inhibitor.Its main function is to neutralize the release of elastase by neutrophils in the inflammatory response.The deficiency of Alpha-1-antitrypsin may lead to lung failure to inhibit tissue destruction induced by elastase. Alpha-1-antitrypsin deficiency is associated with acinar emphysema and liver disease.In the liver, deficiency of c-1-antitrypsin may cause neonatal hepatitis or cirrhosis of the liver in some individuals during adolescence or adulthood.
| Product Name | Alpha-1 Antitrypsin(polyclonal),RPab |
| Catalog No. | CAR-0110 |
| Intended Use | IVD, RUO |
| Species Reactivity | Human; others not tested |
| Cellular Localization | Cytoplasm / Nucleus |
| Antibody Type | Rabbit Monoclonal |
| Clone | Polyclonal |
| Format and Volume | Ready-to-use: 1mL, 3mL, 6mL Concentrated: 0.1mL, 0.2mL and 1mL |
| IVD Datasheet (IFU) | ↕️ Download |
| RUO Datasheet (IFU) | ↕️ Download |
| SDS sheet | check with sales |
Store at 2~8°C. Avoid freezing.
Maintain temperature below room temperature during transport, ensuring it does not exceed one week.