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P21(DCS-60.2),MMab
P21 protein sits in normal cells in the form of tetrameric complex which formed with cell cyclin, cyclin dependent kinase(CDK), and proliferating cell nucleoantigen as well as proliferation cellular nuclear antigen. In addition to inhibit phosphorylating of RB protein, and to cause the cell cycle to stall in the G1 phase. Ras cancer gene activation can be mutated by the point mutations of the 12th, 13th, 59th, 61th genetic code, or by gene amplification. Because of the activation of Ras cancer gene, the P21 protein will occur abnormal expression. P21 protein has the higher conservative in term of evolution and has a G-protein function.The GTP enzyme of mutated P21 protein decreases the activity, then it can not carry on the hydrolysis from GTP to GDP quickly.Thus, the cell produces a continuous proliferation, which eventually leads to cell cancer. The results show that P21-Ras is normal and atypical proliferating in the general hyperplasia of the breast catheter epithelial and the expression in the invasive ductal carcinoma is increased. The positive expression rate in lung cancer can reach 72.94%.
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Staining Tissue
[As Figure shows]
Colon cancer tissue stained with P21
[Intended Use]
This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist.
[Specifications]
| Product Name | P21(DCS-60.2),MMab |
| Catalog No. | CPM-0111 |
| Intended Use | IVD, RUO |
| Species Reactivity | Human; others not tested |
| Cellular Localization | Cytoplasm / Nucleus |
| Antibody Type | Mouse Monoclonal |
| Clone | DCS-60.2 |
| Format and Volume | Ready-to-use: 1mL, 3mL, 6mL Concentrated: 0.1mL, 0.2mL and 1mL |
[Datasheets & SDS]
| IVD Datasheet (IFU) | ↕️ Download |
| RUO Datasheet (IFU) | ↕️ Download |
| SDS sheet | check with sales |
[Storage and Validity]
Store at 2~8°C. Avoid freezing.
Maintain temperature below room temperature during transport, ensuring it does not exceed one week.
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