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TRPS1(EPR16171),RMab
Trichorhinophalangeal syndrome type 1 (TRPS1) as a specific gene for breast carcinoma across 31 solid tumor types. Moreover, high mRNA level of TRPS1 was found in all four subtypes of breast carcinoma including ER/PR-positive luminal A and B types, HER2-positive type, and basal-type/TNBC. We then analyzed TRPS1 expression in 479 cases of various types of breast cancer using immunochemistry staining, and found that TRPS1 and GATA3 had comparable positive expression in ER-positive (98% vs. 95%) and HER2-positive (87% vs. 88%) breast carcinomas. However, TRPS1 which was highly expressed in TNBC, was significantly higher than GATA3 expression in metaplastic (86% vs. 21%) and nonmetaplastic (86% vs. 51%) TNBC. In addition, TRPS1 expression was evaluated in 1234 cases of solid tumor from different organs. In contrast to the high expression of GATA3 in urothelial carcinoma, TRPS1 showed no or little expression in urothelial carcinomas or in other tumor types including lung adenocarcinoma, pancreatic adenocarcinoma, colon and gastric adenocarcinoma, renal cell carcinoma, melanoma, and ovarian carcinoma.
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Product Feature
[As Figure shows]
Tonsil tissue stained with CD79a
[Intended Use]
This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist.
[Specifications]
| Product Name | TRPS1(EPR16171),RMab |
| Catalog No. | CTR-0300 |
| Intended Use | IVD, RUO |
| Species Reactivity | Human; others not tested |
| Cellular Localization | Nuclei |
| Antibody Type | Rabbit Monoclonal |
| Clone | EPR16171 |
| Format and Volume | Ready-to-use: 1mL, 3mL, 6mL Concentrated: 0.1mL, 0.2mL and 1mL |
[Datasheets & SDS]
| IVD Datasheet (IFU) | ↕️ Download |
| RUO Datasheet (IFU) | ↕️ Download |
| SDS sheet | check with sales |
[Storage and Validity]
Store at 2~8°C. Avoid freezing.
Maintain temperature below room temperature during transport, ensuring it does not exceed one week.
[Others]
-Diagnosing ER positive breast cancer (> 95%), HER2 positive breast cancer (> 90%), triple negative breast cancer (> 90%, including metaplastic and nonmetaplastic triple negative breast cancer) (Mod Pathol 2021;34:710, Am J Surg Pathol 2022;46:415, Hum Pathol 2022;125:97)
In a panel along with pancytokeratin, ER and GATA3 to diagnose metastatic carcinoma of breast origin (Hum Pathol 2022 Apr 14 [Epub ahead of print])
Differentiating GATA3 positive invasive breast cancer from GATA3 positive urothelial carcinoma
Differentiating invasive breast carcinoma from adenocarcinomas of nonbreast origin (such as adenocarcinoma from lung, GI, pancreas, etc.)
Differentiating triple negative breast cancer from melanoma
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