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DOG1(C2E3), MMab
DOG1 (discovered on GIST 1) is a cell-surface protein with an unknown function. It is highly expressed on the cell surface of gastrointestinal stromal tumors (GISTs) and is rarely expressed in other types of soft tissue tumors. When compared to a c-Kit antibody, the DOG1 antibody has been shown to identify 11% more GIST cases with c-Kit mutations.
The DOG1 antibody is particularly useful in identifying GIST cases that are negative for c-Kit expression or have PDGFRA mutations. These cases may still benefit from treatment with imatinib mesylate (Gleevec), which is an inhibitor of the kit tyrosine kinase. In addition, DOG1 immunoreactivity is observed in fewer cases of mesenchymal and epithelial tumors, as well as melanomas, when compared to c-Kit. By using this highly sensitive and specific marker, the accuracy of GIST diagnosis can be increased.
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Product Features
[Intended Use]
This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist.
[Specifications]
| Product Name | DOG1(C2E3), MMab |
| Catalog No. | CDM-0033 |
| Intended Use | IVD, RUO |
| Species Reactivity | Human; others not tested |
| Cellular Localization | Cytoplasm / Nucleus |
| Antibody Type | Mouse Monoclonal |
| Clone | C2E3 |
| Format and Volume | Ready-to-use: 1mL, 3mL, 6mL Concentrated: 0.1mL, 0.2mL and 1mL |
[Datasheets & SDS]
| IVD Datasheet (IFU) | ↕️ Download |
| RUO Datasheet (IFU) | ↕️ Download |
| SDS sheet | check with sales |
[Storage and Validity]
Store at 2~8°C. Avoid freezing.
Maintain temperature below room temperature during transport, ensuring it does not exceed one week.
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