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CK5/6/TTF-1 detection reagent (Immunohistochemical)
CK5/6/TTF-1 detection reagent (Immunohistochemical) is mainly used to qualitatively identify TTF-1 and CK5/6 proteins. Using immunohistochemical dual staining detection and multiple antibody combination technology, there are detected two antigen targets at the same time on the same sample tissue section by one staining process.
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Specification
|
Model Number |
Specification |
|
SD8103 |
1mL/pcs; 3mL/pcs; 7/pcs |
This antibody is used with Immune Chromogenic Reagent (Dual Staining I) (SD8001)
Clone: C6H1/C1C8 + Mym1-TTF1
More Info
CK5/6 is mainly expressed in the cell membrane and cytoplasm of squamous epithelial cells or squamous cells. It is almost not expressed in glandular epithelium. CK5/6 has a good differential diagnosis effect for squamous cell carcinoma and adenocarcinoma.
TTF-1 is expressed in the nucleus of thyroid follicular epithelium and alveolar epithelial cells. It is the primary marker for the differential diagnosis of lung adenocarcinoma. TTF-1 is expressed in more than 70% of non-mucinous adenocarcinoma subtypes, small cell lung cancer, a small portion of undifferentiated large cell lung cancer and atypical carcinoids, a small number of typical carcinoids.
CK5/6 is a marker of mesothelioma. TTF-1 is almost not expressed in mesothelioma. Combined detection of the two markers can be used to differentially diagnose mesothelioma and lung adenocarcinoma. The combination of CK5/6 and TTF-1 antibody is used to detect most lung cancers, and only one target is positive. When the two antibodies are expressed together, it may be a sign of adenosquamous carcinoma. CK5/6/TTF-1 can help distinguish lung adenocarcinoma from lung squamous cell carcinoma.
lung squamous cell carcinoma TTF-1-nucleus (positive) CK5/6-cytoplasm (brown)
lung squamous cell carcinoma TTF-1-nucleus ((brown) CK5/6-cytoplasm (positive)
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