A total of 156 datas
Desmoglein-3 is a protein encoded by the DSG3 gene on chromosome 18. Desmoglein-3 is a calcium-binding transmembrane glycoprotein. Four desmoglein subfamily members have been identified, all of which are members of the cadherin cell adhesion molecule superfamily. This protein has been identified as an autoantigen in the autoimmune skin blistering disease pemphigus vulgaris. DSG-3 is a specific marker for tumor-like squamous cell carcinoma and helps to distinguish squamous cell carcinoma from lung adenocarcinoma.
DOG1 is a protein with a currently unclear function, with the gene located at 11q13 and the protein structure having 8 transmembrane functional domains. It is selectively expressed in gastrointestinal stromal tumors (GISTs) and is mainly used for the diagnosis of GISTs, with positive expression in leiomyosarcomas and synovial sarcomas.
Desmin is an intermediate filament protein with a molecular weight of 53 kDa, expressed in normal smooth muscle, skeletal muscle, cardiac muscle, and myoepithelial cells. This antibody can label leiomyomas and rhabdomyosarcomas, and can be used to determine the myogenic components and their metaplasia in tumors, which is helpful for the research of uterine, skin, gastrointestinal, and other rhabdomyosarcomas and myoepithelial carcinomas.
D2-40 is mainly expressed in lymphatic endothelial cells, fetal testicular tissue, and testicular germ cell tumors, but not in microvascular endothelial cells. This antibody is a new marker for lymphatic endothelium in normal and tumor tissues, and can be used in combination with endothelial cell markers for the diagnosis of tumors of lymphatic endothelial origin.
CD42b is a surface membrane glycoprotein involved in platelet adhesion to the vascular wall and is expressed on the membranes of megakaryocytes and platelets. Loss of CD42b expression in platelets leads to the development of giant platelet disorders. This marker can be used to distinguish subtypes of acute megakaryoblastic leukemia.
Cyclins are regulatory factors of cyclin-dependent kinases. Different cyclins control different specific phases of the cell cycle. Cyclin D1 is an important regulatory product for the G1 to S phase transition in the cell cycle. It promotes DNA synthesis and accelerates cell proliferation by activating Cdk4 or Cdk6. It is mainly used for the research of B-cell lymphoma, breast cancer, head and neck squamous cell carcinoma, esophageal cancer, liver cancer, and lung cancer.
Cytokeratin 5 (CK5) is a type II cytokeratin found in squamous epithelium, mammary myoepithelial cells, and basal cells of the prostate. Cytokeratin 14 (CK14) is a type I polypeptide identified in squamous epithelial cells, certain glandular epithelial cells, myoepithelial cells, and basal cells. Together, they form part of the cytoskeletal framework of epithelial cells. CK5 is expressed in most epithelial mesotheliomas but is not expressed in the majority of lung adenocarcinomas. CK14 antibodies label the basal layer of stratified squamous epithelium and non-squamous epithelium and can identify basal cell carcinoma and squamous cell carcinoma. Anti-CK5 in combination with anti-CK14 is used to identify the basal-like phenotype of breast cancer.
Claudin 18.2 belongs to the tight junction protein family. In tumors, tight junctions are destroyed and Claudin protein loses its main function. Claudin 18.2 is only transiently expressed in gastric epithelial cells, and is almost not expressed in other normal tissues. After changes in gastric tissue, its expression increases. High expression can also be seen in pancreatic cancer, lung cancer, esophageal cancer, and ovarian cancer. Antibody drugs targeting Claudin 18.2 can significantly improve the survival rate of patients.
Cytokeratin 4 (CK4) is a type II cytokeratin that is specifically expressed, together with cytokeratin 13, in the differentiated layers of the esophagus and mucosal epithelium. Mutations in the gene encoding this protein (KRT4) are associated with white sponge nevus, a condition characterized by white lesions of the oral cavity, esophagus, and anal mucosa. Reduced expression of CK4 is associated with head and neck squamous cell carcinoma, and it is useful in distinguishing esophageal squamous cell carcinoma from thyroid-derived squamous cell carcinoma.
The human cyclin E gene encodes several polypeptides with a molecular weight range of 39 to 52 kDa. Cyclin E1 is expressed during the transition from the late G1 phase to the S phase of the cell cycle. The expression of Cyclin E1 in malignant tumors is higher than that in normal proliferating cells. The expression of this protein is related to the progression of different cancers, such as breast cancer, leukemia, lymphoma, and other types of tumors.
Integrin alpha M (ITGAM) is a protein subunit that forms the macrophage antigen (Mac-1) or complement receptor 3 (CR3). ITGAM, also known as CR3A and CD11b, is a common myeloid marker. It has a 50% positive expression rate in acute myeloid leukemia. Co-detection of CD117 and CD11b helps to distinguish acute promyelocytic leukemia (CD11b negative) from cases of recovering benign proliferation (CD117 negative, CD11b positive).
COX-2 is a membrane-bound enzyme that participates in the response of cell growth factors, tumor promoters, and cytokines. It is highly expressed in lung cancer, breast cancer, and colon cancer. COX-2 inhibitors have anti-tumor effects, so it is one of the targets for tumor therapy.
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