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FLI-1(MRQ-1),MMab

FLI-1 is used to label Ewing's sarcoma/primitive neuroectodermal tumors, with specificity and sensitivity superior to CD99. It is also a new type of vascular endothelial marker, with specificity and sensitivity as good as CD31 and CD34. Its positive site is located in the nucleus and is easy to observe.

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Factor VIII(36B11),MMab

Human von Willebrand factor (also known as Factor VIII-related antigen) is a multimeric glycoprotein with a molecular weight of 270 kD. It mediates the adhesion of platelets to damaged blood vessel walls and is a carrier and stabilizer for coagulation factor VIII. It is reported to be expressed in platelets, megakaryocytes, and various tumors, including hemangiomas, angiosarcomas, and Kaposi's sarcomas.

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Factor XIIIa(EP3372), RMab

Factor XIIIa is a β-globulin found in the blood. It is useful in the differential diagnosis of dermatofibroma (90%+), dermatofibrosarcoma protuberans (25%+), and desmoplastic malignant melanoma (0%+).

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EZH2(11),Mmab

The EZH2 (Enhancer of Zeste Homolog 2, EZH2) gene is related to cell growth regulation. EZH2 can inhibit target genes in the chromatin structure and promote cell proliferation. Its high expression stimulates the spread of tumor cells and is highly expressed in a variety of tumor tissues.

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Estrogen Receptor(C6H7),MMab

Cel novte Bio's ER antibody is the first approved ER semi-quantitative immunohistochemistry diagnostic antibody in China, with registration number 2021340072. During the research and development and registration process, it has undergone multi-center clinical comparisons with the internationally optimal semi-quantitative clones, and the consistency with the control product has reached 93.326%. The staining is accurate, specific, and clearly localized, providing more reliable staining results for clinical pathological diagnosis. The ER receptor is present in the endometrium, myometrium, normal breast epithelial cells, and some (about 50-60% of breast cancer patients) breast cancer cell nuclei. Studies have shown that ER-positive breast cancer patients are effective in hormone therapy and have a better prognosis than ER-negative patients. Therefore, ER, PR, and C-erbB-2 are used together to guide patient treatment.

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ERG(C12A8),RMab

About 50% of prostate cancers have gene fusion mutations. TMPRSS2:ERG is the most common fusion gene, which is closely related to the invasiveness and prognosis of prostate cancer. ERG-positive cases often have a higher prostate cancer stage, a high recurrence rate, and pelvic lymph node metastasis.

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ERCC1(EP219),RMab

ERCC1 is a highly conserved excision endonuclease in the nucleotide excision repair pathway and is a necessary condition for the effective repair of DNA complexes induced by alkylating agents. The prognosis of ERCC1 protein- positive patients with non-chemotherapy is better than that of patients receiving chemotherapy.

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Epithelial Specific Antigen/Ep-CAM (C5C9), MMab

The epithelial antigen is widely distributed in epithelial cells and has highly conserved expression characteristics in tumors of epithelial origin. The positive reaction of adenocarcinoma cells is diffuse cytoplasmic and membrane staining, while mesothelioma is focal cytoplasmic staining or negative expression in a small number of cell populations.

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EMA (E29), MMab

EMA is a group of glycoproteins widely distributed on the cell membranes of various normal epithelial cells and their tumors. The distribution range is similar to that of cyto keratin, but the expression in visceral glandular epithelium is better than that of cyto keratin. Therefore, for epithelial-derived tumors, especially poorly differentiated carcinomas, it is best to use it in combination with cyto keratin to improve the positive rate. EMA high- temperature repair can enhance the staining intensity.

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EGFR(EP22),RMab

Epidermal growth factor receptor (EGFR) is a member of the ErbB family, which comprises four closely related receptor tyrosine kinase subunits: EGFR, HER-2/neu, HER-3, and HER-4. EGFR is primarily studied in the context of various tumors, as its overexpression is associated with the development and progression of numerous cancers. In malignant epithelial tumors, EGFR overexpression indicates a poor prognosis; in breast cancer, it predicts shorter survival and reduced efficacy of hormonal therapy.

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E-Cadherin(C12A15),RMab

E-Cadherin n is a Ca²⁺-dependent cell adhesion molecule that plays an important role in the growth, development, and intercellular adhesion of epithelial cells. The structural abnormalities of most tumors and the loss of adhesion they cause are considered to be important steps in local invasion and development. E-Cadherin may play a role in tumor progression, especially as an inhibitor of invasion. For example, in prostate cancer, E-Cadherin expression is reduced or absent, while normal prostate is strongly expressed. In primary breast tumors, the expression of E-Cadherin n and α, β, γ-catenin is reduced or absent, and these four proteins are related to the development of metastasis. The main use of E-Cadherin protein immunohistochemistry is in the significantly different expression in breast lo bu carcinoma and ductal carcinoma.

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Epstein-Barr Virus (LMP-1) (CS1/CS2/CS3/CS4Cocktail), MMab

Epstein-Barr virus (EBV) is one of eight known human herpesviruses and belongs to the Gammaherpesvirinae subfamily, sharing this subfamily classification with Human Herpesvirus 8 (HHV-8). Herpesviruses possess a large double-stranded DNA genome and are complex viruses, typically encoding more than 35 proteins. These include not only viral structural proteins but also enzymes involved in nucleic acid metabolism, DNA synthesis, and protein processing. These viruses establish latency in the host, during which no obvious symptoms of infection are apparent, and the level of infectious agent is very low. During latency, viral gene expression is restricted to a small number of genes. Latent membrane protein 1 (LMP-1) is a 60 kDa protein encoded by the BNLFI gene of EBV.

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