A total of 114 datas
CD138 is a transmembrane heparan sulfate proteoglycan and an important component of the extracellular matrix and plasma membrane. It is expressed at different stages of normal lymphocyte differentiation, including plasma cells, plasmablasts, and immunoblasts, and shows positive expression in plasmacytomas. CD138 is also expressed in certain epithelial cells, vascular smooth muscle cells, endothelial cells, and neural cells. In head and neck squamous cell carcinoma, positive CD138 expression is associated with a favorable prognosis.
The proto-oncogene c-Kit encodes a transmembrane receptor with tyrosine kinase activity, c-Kit (CD117), which is closely related to the platelet-derived growth factor receptor family. c-Kit plays important roles in hematopoiesis, gametogenesis, and melanogenesis. Expression of the CD117 antigen is of significant importance in the study of gastrointestinal stromal tumors (GIST), small cell lung carcinoma, and melanoma.
CD103 is expressed in almost all hair-cell leukemias, not in most b-cell tumors, but in isolated cases of splenic marginal lymphoma.CD103 is mainly expressed in mononuclear cell lines in the interfollicular region of the lymph nodes and in the epithelial cells of the overlying mucosa located in the basement membrane of the tonsil.
CD21, also known as Ⅱ complement receptor and EB virus receptors, complement activation regulator is a member of the family. They are mainly distributed in mature B cells, dendritic cells in lymphatic follicles and some T cells.The function of CD21 promotes the proliferation of B cells, mediates the transformation of EBV into B cells, and CD21 is involved in immune memory.It is mainly used for the diagnosis of follicular dendritic cells and their tumors and the study of the regulation of immune complement activation.
CD19 is a member of the immunoglobulin super family with two immunoglobulin-like domains. It is a single-chain glycoprotein present on the surface of B lymphocytes and follicular dendritic cells of the hematopoietic system. CD19 is an important regulator of B-cell development, activation, and differentiation. On B cells, CD19 forms a signaling complex with CD21, CD81, and CD225 (Leu-13). CD19 is expressed from the earliest recognizable B-cell lineage, through development, to the B-cell differentiation stage, but is not expressed by mature plasma cells.
CD16 is a low-affinity Fc receptor, mainly present on the surface of natural killer cells, neutrophils, monocytes, and macrophages. In immunohistochemistry, CD16 can be used to differentiate yδ T-celllymphoma and yδ T-cell large granular lymphocytic leukemia from peripheral T-cell lymphomas. It has been reported that high infiltration of CD16-positive cells in colorectal cancer patients is associated with improved overall survival.
The CD14 antigen is a 55 kDa glycosylphosphatidylinositol (GPl)-linked glycoprotein. It is reported that the CD14 antigen is expressed on myeloid monocytic lineages including monocytes, macrophages, and Langerhans cells. It is expressed at low levels on neutrophils and B cells. The CD14 antigen is a bacterial receptor that promotes phagocytosis of bacteria by phagocytes or promotes the action of macrophage LPS on particulate matter.These proteins act as an opsonin and an opsonin receptor, respectively, thereby promoting the phagocytosis of bacteria by phagocytes and facilitating the uptake of LPS-coated particulate matter by macrophages.
CD13 is expressed on most peripheral blood monocytes and granulocytes, as well as on most acutemyeloid leukemias, chronic myeloid leukemias, and a few lymphocytic leukemias and myeloid cell lines. CD13 is also present on fibroblasts, endothe lial cells, renal proximal tubule epithelial cells, spinal cordstromal cells, osteoclasts, and renal tubular cells.
CD11c is a member of the integrin family of adhesion proteins. It is reported that CD11c is mainly expressed in myeloid cells such as myelocytes, promyelocytes, metamyelocytes, and non-segmented and segmented neutrophils in normal tissues. It is highly expressed on the surface of tissue macrophages and monocytes, and at low levels in granulocytes. It has been reported to be expressed in NK cells, activatedT cells, and lymphoid lineages, including hairy cell leukemia and some dendritic cells. The CD11c antigen is a practical marker for monocytic differentiation in the classification of a cute myeloid leukemia and a practical indicator for the identification of hairy cell leukemia.
CD7 is a 40 kDa membrane-bound protein, the earliest T-lymphocyte-specific antigen expressed, and the only early marker present throughout T-cell differentiation. This antibody can be used to detect normal human T cells and for the classification of lymphomas and leukemias.
The CD4 antigen is expressed in the (helper/inducer) T cell subset, which accounts for 45% of peripheral blood lymphocytes, and is expressed at lower levels in monocytes. Most cutaneous T-cell lymphomas, including mycosis fungoides, express the CD4 antigen. HTLV-1-associated adult T-cell leukemia/lymphoma is also usually CD4 positive.
The CD3 molecule is composed of five different polypeptide chains and is expressed on the surface of all mature T cells. This antibody reacts with a cytoplasmic protein of T cells, the CD3 antigen. T cells in thethymic cortex, medulla, and peripheral lymphoid tissues are all stained. This antibody is suitable for the diagnosis of T cells in formalin-fixed, Paraffin-embedded normal and tumor tissues.
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