A total of 178 datas
Prolactin (PRL) is a polypeptide hormone secreted by lactotroph cells in the anterior pituitary gland. Its primary function is to stimulate milk production. Prolactin IHC is used for the functional classification of pituitary adenomas, specifically for identifying prolactin-secreting pituitary adenomas (prolactinomas).
PMS2 is a mismatch repair protein with a molecular weight of 90 kDa, encoded by a gene located on chromosome 7. Under normal physiological conditions, PMs2 typically functions alongside MSH2, MSH6,and MLH1 to monitor DNA replication and correct genetic mutations that may arise from base mismatches or" spelling errorsduring the process. Deficiency of this gene accounts for a small but significant proportion of colorectal cancers and the majority of tumors exhibiting microsatellite instability.
Hepatoblastoma has been reported as the most common primary liver tumor in children. It is sometimes difficult to distinguish hepatoblastoma from other small round cell tumors in children, especially the embryonal type of hepatoblastoma. Expression of hepatocyte-specific antigen, alpha-fetoprotein (AFP) , or carcinoembryonic antigen (CEA) has been detected in both normal fetal hepatocytes and malignant hepatocytes.
HLA-DR is an MHC class ll molecule consisting of two subunits with molecular weights of 36 kDa and 27 KDa( a subunit and B subunit, respectively) . HLA-DR is expressed on B lymphocytes, monocytes,macrophages, activated T lymphocytes, activated NK lymphocytes, and human progenitor cells. It is also expressed on thymic epithelial cells, in B lymphocyte-dependent areas of the spleen and lymph nodes, and in B-cell lymphomas. HLA-DR is co-expressed with CDla on epidermal Langerhans cells.
Herpes simplex virus type 2 (HSV-2) is a member of the herpesvirus family, which also includes herpes simplex virus type 1 (HSV-1) , Epstein-Barr virus (EBV) , and varicella-zoster virus (VZv) . Distinguishing between. HSV-1 and HSV-2 is particularly challenging. The complete virion consists of a core, capsid tegumen, and envelope. The core contains double-stranded DNA wound into a filamentous spool, while the capsid exhibits icosahedral symmetry. These viruses can enter a latent phase during which there are no obvious signs of infection and the level of infectious virus becomes very low. During latency, the viral DNA may integrate into the host cell genome.
Human papillomavirus (HPV) is a widespread DNA virus in nature. It is a spherical DNA virus that can cause various benign papillomas or warts on human skin and mucous membranes. HPV has multiple subtypes,and infection with certain subtypes has potential carcinogenicity. This antibody is primarily used for condyloma acuminatum, cervical cancer, and anal cancer.
Human Growth hormone (HGH) is a hormone synthesized and secreted by somatotroph cells in the anterior pituitary gland. It promotes protein synthesis and skeletal development. This antibody reacts with human GH and shows weak cross-reactivity with hormones such as PRL, TSH, LH, and FSH. It is primarily used in the functional classification of pituitary adenomas.
HCG, also known as human chorionic gonadotropin, is a glycoprotein secreted by placental trophoblastic cells and is highly expressed in the chorionic trophoblasts during pregnancy. It is primarily used in the diagnosis of choriocarcinoma and malignant hydatidiform mole. HCG is also expressed in germ cell tumors such as embryonal carcinoma and seminoma. In addition, HCG expression has been observed in ovarian cancer, breast cancer, lung cancer, and malignant melanoma.
HCG, aiso known as human chorionic gonadotropin, is a glycoprotein secreted by placental trophoblastic cells and is highly expressed in the chorionic trophoblasts during pregnancy. It is primarily used in the diagnosis of choriocarcinoma and malignant hydatidiform mole. HCG is also expressed in germ cell tumors such as embryonal carcinoma and seminoma. In addition, HcG expression has been observed in ovarian cancer, breast cancer, lung cancer, and malignant melanoma.
IMP3 (linsulin-like growth factor l mRNA-binding protein 3) is an oncofetal RNA-binding protein composed of 580amino acids and containing four K-homology domains. llP3 is typically expressed in early embryonic tissues but isalso re-exoressed in a proportion of neoplastic cells originating from non-small cell lung carcinoma and pancreaticadenocarcinoma. Additionally, some cancers arising from other organs such as the bladder, cervix, colonesophagus, and stomach have also been found to express llP3. This antibody can serve as a useful marker foidistinguishing between benign and malignant tissues.
This antibody reacts with the y chain of immunoglobulin G (lgG). it is of certain auxiliary significance in thedifferential diagnosis of lymphomas, plasmacytomas, and Hodgkin lymphomas of B-cell origin. it can alsobe used for the functional classification of glomerulonephritis.
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