PRIMARY ANTIBODY

Glypican 3(1G12),MMab

The Glypican family consists of six members, each composed of a core protein linked to glycosaminoglycan (GAG) chains. The Glypican-3 (GPC3) gene is located on human chromosome Xq26.1 and encodes a 580-amino-acid extracellular glycoprotein with a relative molecular mass of 66 kDa. GPC3 is involved in regulating cell proliferation, differentiation, adhesion, and migration. It may also play a role in inhibiting or modulating the growth of most mesodermal tissues and organs. GPC3 expression is upregulated in various malignant tumors. Recent studies indicate that Glypican-3 holds significant value in distinguishing between benign and malignant tumors.

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Glutamine Synthetase (C6E12), MMab

Glutamine synthetase (GS) catalyzes the formation of glutamine from glutamate and ammonia in the mammalian liver. In normal liver tissue, GS expression is restricted to centrilobular hepatocytes (those surrounding the central vein) and is absent in periportal hepatocytes. Glutamine synthetase has been established as a marker for hepatocellular carcinoma (HCC). It is expressed in the majority of HCC cases, including 70% of early-stage HCC and 59% of poorly differentiated HCC.

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Glutamine Synthetase(GS-6),MMab

Glutamine synthetase (GS) catalyzes the formation of glutamine from glutamate and ammonia in the mammalian liver. In normal liver tissue, GS expression is restricted to centrilobular hepatocytes (those surrounding the central vein) and is absent in periportal hepatocytes. Glutamine synthetase has been established as a marker for hepatocellular carcinoma (HCC). It is expressed in the majority of HCC cases, including 70% of early-stage HCC and 59% of poorly differentiated HCC.

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Glial Fibrillary Acidic Protein (C2C6), MMab

Glial fibrillary acidic protein (GFAP) is an intermediate filament protein with a molecular weight of 52 kDa. It has been reported to be expressed in glial cells, such as astrocytes and ependymal cells. In the peripheral nervous system, GFAP is expressed in Schwann cells, enteric glial cells, and satellite cells of human sensory ganglia. In neoplastic tissues, GFAP expression is observed in astrocytomas and ependymomas.

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Glial Fibrillary Acidic Protein(GA5),MMab

Glial fibrillary acidic protein (GFAP) is an intermediate filament protein with a molecular weight of 52 kDa. It has been reported to be expressed in glial cells, such as astrocytes and ependymal cells. In the peripheral nervous system, GFAP is expressed in Schwann cells, enteric glial cells, and satellite cells of human sensory ganglia. In neoplastic tissues, GFAP expression is observed in astrocytomas and ependymomas.

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GCDFP-15(23A3),MMab

Mammary cystic disease is a benign lesion of the breast occurring in premenopausal women, with cysts being the primary pathological alteration. Cytosolic analysis of normal tissue specimens from all major organs has demonstrated that GCDP-15 protein is present in apocrine epithelium, the lacrimal sac, ceruminous and Moll's glands, as well as in the serous cells of the majority of submandibular glands, trachea, bronchi, sublingual glands, and minor salivary glands. GCDP-15 has been detected at various concentrations in the cytosol of breast cancer tissues, with the highest concentrations observed in well-differentiated breast carcinomas. In normal breast lobules and small ducts, only occasional epithelial cells test positive for GCDP-15. Expression has also been reported in areas of apocrine metaplasia within fibroadenomas. Furthermore, GCDP-15 has been reported to be co-expressed with prostate-specific antigen (PSA) in androgen receptor-positive breast tumors.

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GATA3(L50-823),MMab

GATA3 binds to the DNA sequence (A/T)GATA(A/G) and is a zinc finger transcription factor that plays an important role in promoting and guiding cell proliferation, development, and differentiation in many tissues and cell types. It is reported that GATA3 is expressed in breast cancer and urothelial carcinoma, but rarely in other tumors. GATA3 is expressed in all breast lobular carcinomas and 91% of invasive ductal carcinomas (grade I: 100%, grade II: 89%, grade III: 86%). At the same time, GATA3 expression in breast cancer is positively correlated with ER and PR, and negatively correlated with HER-2. GATA3 is also expressed in urothelial carcinoma, especially in invasive and high-grade tumors. Therefore, GATA3 can be used for the differential diagnosis of urothelial carcinoma and tumors of unknown origin.

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Gastrin(polyclonal),RPab

Gastrin is present in normal human gastric antrum (pyloric) mucosal cells (G cells), duodenal glands, and Brunner's glands. This antibody is used to label gastrin-secreting cells and related tumors, and is helpful for the diagnosis and research of G-cell hyperplasia and gastrinoma.

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Galectin-3 (C6C10), MMab

Galectin-3 is a member of the β-galactoside-binding lectin family. It is involved in several biological activities, including being embedded in the laminin layer of the basement membrane glycoprotein. Cell surface Galectin-3 may be involved in homotypic cell adhesion and is downregulated in colon cancer progression. A similar downregulation has been reported in breast cancer. The downregulation of Galectin-3 may be one of the many mechanisms that allow cancer cells to interact with laminin, thereby promoting cancer cell invasion and metastasis. Its activated invasive phenotype has been confirmed in many types of tumors. It has been reported that Galectin-3 is detected in anaplastic large cell lymphoma, but not in different types of Hodgkin's disease or Reed- Sternberg cells. As a 30 kD protein, it is mainly expressed in the nucleus, cytoplasm, mitochondria, cell surface, and extracellular matrix. It is mainly used for the differential diagnosis of thyroid follicular adenoma, follicular carcinoma, and papillary carcinoma. At the same time, based on its strong positive expression in the negative-like invasion of microinvasive follicular carcinoma, it guides the identification of follicular adenoma and microinvasive carcinoma.

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Galectin-3(EP412),RMab

Galectin-3 is a member of the β-galactoside-binding lectin family. It is involved in several biological activities, including being embedded in the laminin layer of the basement membrane glycoprotein. Cell surface Galectin-3 may be involved in homotypic cell adhesion and is downregulated in colon cancer progression. A similar downregulation has been reported in breast cancer. The downregulation of Galectin-3 may be one of the many mechanisms that allow cancer cells to interact with laminin, thereby promoting cancer cell invasion and metastasis. Its activated invasive phenotype has been confirmed in many types of tumors. It has been reported that Galectin-3 is detected in anaplastic large cell lymphoma, but not in different types of Hodgkin's disease or Reed- Sternberg cells. As a 30 kD protein, it is mainly expressed in the nucleus, cytoplasm, mitochondria, cell surface, and extracellular matrix. It is mainly used for the differential diagnosis of thyroid follicular adenoma, follicular carcinoma, and papillary carcinoma. At the same time, based on its strong positive expression in the negative-like invasion of microinvasive follicular carcinoma, it guides the identification of follicular adenoma and microinvasive carcinoma.

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FSH(EP257),RMab

Follicle-stimulating hormone is a hormone secreted by the pituitary gland. In women, it can promote the proliferation and development of follicles; in men, it can promote the production of sperm. This antibody reacts with human FSH and is mainly used for the functional classification of pituitary adenomas and the diagnosis of pituitary adenomas and metastatic tumors.

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FOXP1(BP6112),RMab

FOXP1 protein is a winged-helix transcription factor that is upregulated during B-cell activation. FOXP1 is a prognostic indicator for diffuse large B- cell lymphoma, especially in germinal center-type diffuse large B-cell lymphoma, where positivity suggests a poor prognosis.

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