/ Products / IHC / MULTIPLEX IHC / TTF-1/Napsin A detection reagent (Immunohistochemical) /

TTF-1/Napsin A detection reagent (Immunohistochemical)

TTF-1/Napsin A detection reagent (Immunohistochemical) is mainly used to qualitatively identify TTF-1 and Napsin A proteins. Using immunohistochemical dual staining detection and multiple antibody combination technology, there are detected two antigen targets at the same time on the same sample tissue section by one staining process.

Product Feature

a) TTF-1 is a nuclear marker expressed in thyroid follicular cells and alveolar epithelial cells and is widely used in the identification of lung adenocarcinoma.

b) TTF-1 is expressed in most non-mucinous lung adenocarcinomas and may also be positive in small cell lung carcinoma, neuroendocrine tumors, and a small subset of lung squamous cell carcinomas.

c) Napsin A is expressed in normal type II pneumocytes and renal tubular epithelial cells and is positive in approximately 80%–90% of lung adenocarcinomas.

d) Napsin A is usually negative in lung squamous cell carcinoma, supporting its value in distinguishing adenocarcinoma from squamous cell carcinoma.

e) Combined TTF-1 and Napsin A staining provides improved sensitivity for the identification of lung adenocarcinoma.

f) The TTF-1/Napsin A combination supports the differential diagnosis of non-small cell lung cancer, including cases with neuroendocrine features that may mimic adenocarcinoma.