IHC

CD10(C6D1),MMab

The CD10 antigen is widely expressed on the surface of a variety of normal and tumor cells. It has been reported that in other malignant lymphomas, the CD10 antigen is expressed in the cells of lymphoblastic Iymphoma, Burkitt's lymphoma, and follicular lymphoma. The CD10 antigen has been identified on the surface of normal early lymphoblasts, immature cells in adult bone marrow, and germinal center B cells in Iymphoid tissues. The CD10 antigen is also expressed in various non-lymphoid cells and tissues, such as breast myoepithelial cells, fibroblasts, and is particularly highly expressed in the renal brush border and fetal epithelial cells.

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CD8(C2B11),MMab

The CD8 molecule is a 32 kDa glycoprotein composed of two chains, present on the surface of suppressor/cytotoxic Tcells. It is a receptor for MHC class I molecules, and its intracellular part is associated with the p56lck glycoprotein kinase, which regulates the function of the TCR/CD3 complex. This antibody is mainly used to label suppressor/cytotoxic T cells (accounting for about 25-30% of peripheral blood lymphocytes). It is generally used in combination with CD4.

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CD7(C6F3),MMab

CD7 is a 40 kDa membrane-bound protein, the earliest T-lymphocyte-specific antigen expressed, and the only early marker present throughout T-cell differentiation. This antibody can be used to detect normal human T cells and for the classification of lymphomas and leukemias.

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CD7(MRQ-56),MMab

CD7 is a 40 kDa membrane-bound protein, the earliest T-lymphocyte-specific antigen expressed, and the only early marker present throughout T-cell differentiation. This antibody can be used to detect normal human T cells and for the classification of lymphomas and leukemias.

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CD5 (C6A10), MMab

It is reported that the CD5 antigen is expressed in 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, it is mainly observed to be associated with T-cell reactions. The CD5 antigen also reacts with many T-cell leukemias, lymphomas, activated T cells, and some B cells mainly located in the mantle zone of normal lymph nodes. It has also been reported that the CD5 antigen is expressed in acute T-lymphoblastic leukemia (T-ALL), some chronic B-lymphocytic leukemias (B-CLL), and B- and T-cell lymphomas.

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CD3(C3E7),MMab

The CD3 molecule is composed of five different polypeptide chains and is expressed on the surface of all mature T cells. This antibody reacts with a cytoplasmic protein of T cells, the CD3 antigen. T cells in thethymic cortex, medulla, and peripheral lymphoid tissues are all stained. This antibody is suitable for the diagnosis of T cells in formalin-fixed, Paraffin-embedded normal and tumor tissues.

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CD2 (C3G8), MMab

CD2 is expressed on the surface of mature T cells and NK cells. CD2 can promote the recognition ofantigens by T lymphocytes and enhance the adhesion and signal transduction between T lymphocytes, thymocytes, and NK cells with antigen-presenting cells and target cells. This antibody can label normal T cells and their related tumors.

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CD1a(C1E1),MMab

CD1a is expressed on dendritic cells, Langerhans cells of the skin, and cortical thymocytes. CD1a is used for the typing of thymic carcinoma and can also be used for the differential diagnosis of thymic tumors and primary thoracic tumors.

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Cathepsin K(3F9), MMab

Cathepsin K is a lysosomal cysteine protease that can be expressed innormal osteoblasts and fibroblasts. It has been reported that Cathepsin K can be used to distinguish renal cell carcinoma (RCC) from other tumors.

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Calretinin(C5G4),MMab

CR is an intracellular calcium-binding protein belonging to the cal modulin C superfamily. It is mainly used for the diagnosis of mesothelioma, especially epithe lio id mesothelioma, with a sensitivity of up to 100% and a specificity of 50%. It can also be used for the study of nervous system diseases.

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Calponin (C6A12), MMab

Calponin is a calmodu lin-binding protein that binds to myosin and F-actin, and is involved in the regulation of smooth muscle contraction. It is a smooth muscle-specific protein expressed in the cytoplasm of smooth muscle and myoepithelial cells. It is used to label breast myoepithelial and smoothmuscle cell tumors, and myofibroblasts can also be positive.

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Calcitonin(C1C2),MMab

Calcitonin (CT) is a 32-amino acid peptide synthesized by the parafollicular cells of the thyroid gland. It reduces serum calcium levels by inhibiting osteoclast-mediated bone resorption, reducing calcium reabsorption in the kidneys, and reducing intestinal calcium absorption. Its action is therefore opposite to that of parathyroid hormone. The CT gene transcript also encodes calcitonin gene-related peptide (CGRP),which is a potent vasodilator. In thyroid parafollicular cells, 95% of the CT/CGRP is processed and translated to produce CT. However, in nerve cells, 99% of the CT/CGRP RNA is translated into CGRP. Thyroid C-cells cangive rise to endocrine tumors, medullary thyroid carcinoma (MTC), which can be sporadic (75% of cases) or hereditary (25% of cases).

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