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IGH Fusion Gene FISH Probe

Clinic Signification:
1.Multiple myeloma diagnosis and treatment guidelines suggest that FISH detection sites include: IGH translocation, 17p- (P53 deletion), 13q14 deletion, 1q21 amplification. If FISH detects positive IGH translocation, then further testing for t(4;14), t(11;14), t(14;16), t(14;20), etc. The average survival time of MM with t(4;14) is 644 days, but the expression of FGFR3 has no significant relationship with the survival time. The effect of t(4;14) on the prognosis does not depend on FGFR3. MM with t(4; 14) (p16; q32) patients cannot obtain survival advantages even if they receive high-dose chemotherapy.
2.It will have a better effect on patients who have t(11: 14)(q13; q32) translocation to receive chemotherapy combined with autologous hematopoietic stem cell transplantation.
3.t(14;20)(q32;q12), t(14;16)(q32;q23) are high-risk groups, which have short survival time and poor prognosis.