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MMR panel by IHC-MSH6

MSH6 IHC, is a specialized laboratory technique employed in the field of pathology to assess the expression of the MSH6 protein within tissue samples. MSH6 is a crucial component of the DNA mismatch repair (MMR) system, which plays a fundamental role in maintaining the integrity of DNA by correcting errors that arise during DNA replication.

MSH6 IHC is particularly important in the diagnosis and understanding of various genetic conditions and cancers, particularly those associated with hereditary mismatch repair deficiency (HMRD) and Lynch syndrome (hereditary non-polyposis colorectal cancer, or HNPCC). Mutations or abnormalities in MSH6 can lead to MMR deficiency, increasing the risk of developing colorectal cancer, endometrial cancer, and other malignancies.