Lymphatic enhancer factor (LEF-1) belongs to the highly migrating family of components, which plays an important role in cell proliferation, differentiation and apoptosis as a transcription factor-mediated of Wnt signaling pathway in the nucleus of the cell.In chronic lymphocytic leukemia, the high expression of LEF-1 is associated with the development of the disease and adverse prognosis. LEF-1 can be detected the positive exprssion of immunohistochemistry in all malignant cells of chronic lymphocytic leukemia or small lymphocytic lymphocytic lymphocytic disease. LEF-1 had 50% positive expression in follicle lymphoma with high differentiation and 38% positive expression in large B-cell lymphoma,but not in mantle cell lymphoma and marginal zone lymphoma.
Lymphoma tissue stained with LEF1
รหัส |
โซลูชันการทำงาน |
CONCENTRATED SOLUTION |
||||
CLR-0080 |
ข้อมูลจำเพาะ |
1ml |
3 มล. |
6ml |
0.1ml |
0.2ml |
โคลน: EP310
แหล่งที่มา: กระต่าย
การแปล: Nucleus
Pretreatment: Thermal remediation
เนื้อเยื่อที่เกี่ยวข้อง: Paraffin section/Frozen section