Periodic Acid‑Silver Methenamine Stain

The Periodic Acid‑Silver Metheramine Staining method is of great diagnostic value for observing various morphological changes of the glomerular mesangium and basement membrane. It could not be replaced by other special staining method, especially for observing the formation of the nail of the substrate membrane in the membranous nephropathy and the double or multi‑track changes of the amyloidosis nephropathy basement membrane. Meanwhile, it is also sensitive to all kind of fungal stains and easy to be found even there is a small amount of fungi. It can clearly present that the basement membrane in nephropathy, mostly to be utilized for observing the glomerular capillary basement membrane during inflammatory injury such as fracture and hyperplasia, folding and other forms of change.