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Stathmin(C12A34),MMab

Stathmin 1/ oncoprotein 18, also known as STMN1, is a highly conserved 17 kDa protein that mediates the integration of signals from the cellular environment within thecell. Stathmin is involved in the regulation of the microtubule system, preventing microtubule polymerization and promoting microtubule depolymerization. Overexpression of stathmin enhances microtubule depolymerization.

Intended Use

[Storage and Validity]

Store at 2~8°C. Avoid freezing.
Maintain temperature below room temperature during transport, ensuring it does not exceed one week.

Specification

Product Name	Stathmin(C12A34),MMab
Clone	C12A34
Catalog No.	CSM-0230
Positive Site	Cytoplasm
Applicable Tissue	Paraffin section
Pre-treatment	Heat retrieval
Format and Volume	Ready-to-use: 1mL, 3mL, 6mL Concentrated: 0.1mL, 0.2mL and 1mL

Intended Use
Specification

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Surfactant protein A( SP-A) plays a crucial role in maintaining the structural integrity of the respiratory epithelium by reducing surface tension during respiration. Surfactant is a poprotein complex synthesized by alveolar type ll cells and secreted into the alvedli. SP-A is the major phospholipid-assodated glycoprotein in surfactant and a member of the C-type lectin superfamily It also inhibits lipid secretion and enhances phospholipid uptake by alveolar type ll cells. It has been reported that SP-A levels in amniotic fluid reflect fetal lung maturity, and insufficient surfactant protein levels at birth-commonly observed in preterm infants-can lead to respiratory failure. In individual with lung adenocarcinoma hgh aoncentrations of SPAave been reported in pleural effusions. However, in poorly differentiated lung adenocarcinoma SP-A immunoreactivity is sgnificantly reduced Zameanik J, Kodek R. Virchows Arch. 440( 4) : 353-61 (2002)).

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