GATA3(L50-823),MMab

GATA3 binds to the DNA sequence (A/T)GATA(A/G) and is a zinc finger transcription factor that plays an important role in promoting and guiding cell proliferation, development, and differentiation in many tissues and cell types. It is reported that GATA3 is expressed in breast cancer and urothelial carcinoma, but rarely in other tumors. GATA3 is expressed in all breast lobular carcinomas and 91% of invasive ductal carcinomas (grade I: 100%, grade II: 89%, grade III: 86%). At the same time, GATA3 expression in breast cancer is positively correlated with ER and PR, and negatively correlated with HER-2. GATA3 is also expressed in urothelial carcinoma, especially in invasive and high-grade tumors. Therefore, GATA3 can be used for the differential diagnosis of urothelial carcinoma and tumors of unknown origin.

[Storage and Validity]

Store at 2~8°C. Avoid freezing. 
Maintain temperature below room temperature during transport, ensuring it does not exceed one week.