Pathology Products & Laboratory Equipment

BCA-225(CU-18),MMab

BCA-225 is a glycoprotein expressed in breast carcinoma and cervical cancer. It is a useful marker in the diagnosis of breast cancer and can also be used to differentiate between mesothelioma and adenocarcinoma, with the latter often being positive.

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ARID1A(EPR13501),RMab

ARID1A (AT-rich interactive domain-containing protein 1A) is a key component of the SWI/SNF chromatin remodeling complex. It functions as a tumor suppressor by regulating gene expression through chromatin modification. Loss of nuclear ARID1A expression is a frequent event in several malignancies, most notably ovarian clear cell carcinoma and endometrioid carcinoma. ARID1A IHC is a valuable tool for identifying these molecular subtypes and is often associated with specific clinical outcomes and potential therapeutic vulnerabilities.

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Arginase-1(EP261),RMab

Arginase-1 (ARG-1) is a key urea cycle enzyme primarily expressed in the liver, where it catalyzes theconversion of L-arginine to L-ornithine and urea. ARG-1 is a highly specific and sensitive marker for both benign and malignant hepatocytes. It is currently considered one of the most reliable markers for the differential diagnosis of hepatocellular carcinoma (HCC) from metastatic tumors to the liver. ARG-1 has demonstrated superior sensitivity compared to Hep Par 1 and Glypican 3 in the identification of HCC, particularly in poorly differentiated cases.

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AMACR/p504s(C12A22),MMab

P504S, also known as α-methylacyl coenzyme A racemase (AMACR), is a peroxisomal and mitochondrialenzyme that plays a critical role in bile acid synthesis and the β-oxidation of branched-chain fatty acids. AMACR has been shown to be a highly sensitive and specific marker for prostatic adenocarcinoma. It typically exhibits a strong, granular cytoplasmic staining pattern in malignant prostatic glands, while remaining negative or weakly focal in benign glands. AMACR is frequently used in a triple-stain cocktail with basal cell markers (e.g., p63 and High Molecular Weight Cytokeratin) to increase diagnostic certainty in challenging prostate biopsies.

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AMACR/p504s(13H4),MMab

P504S, also known as α-methylacyl coenzyme A racemase (AMACR), is a peroxisomal and mitochondrial enzyme that plays a critical role in bile acid synthesis and the β-oxidation of branched-chain fatty acids. AMACR has been shown to be a highly sensitive and specific marker for prostatic adenocarcinoma. It typically exhibits a strong, granular cytoplasmic staining pattern in malignant prostatic glands, while remaining negative or weakly focal in benign glands. AMACR is frequently used in a triple-stain cocktail with basal cell markers (e.g., p63 and High Molecular Weight Cytokeratin) to increase diagnostic certainty in challenging prostate biopsies.

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ALK(C4X1),RMab

Anaplastic Lymphoma Kinase (ALK) antibody recognizes the formalin-resistant epitope of the native ALK protein. ALK specifically labels t(2;5)-positive cells, yielding strong cytoplasmic staining that may also beassociated with nuclear staining. ALK expression is a defining feature of a subset of anaplastic large cell lymphomas (ALCL) and is a key prognostic indicator. Furthermore, ALK IHC has emerged as a highly sensitive and cost- effective screening tool for detecting ALK rearrangements in non-small cell lung cancer(NSCLC), guiding the use of targeted tyrosine kinase inhibitor therapies.

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Alpha-1(Antichymotrypsin)(JM83-29), RMab

Alpha-1-Antichymotrypsin (AACT) is a serine protease inhibitor that is a member of the serpinsuperfamily. AACT is expressed in various tissues and is widely used as a marker for histiocytic tumors, including malignant fibrous histiocytoma and histiocytic lymphoma. It is also useful in identifying certaincarcinomas and can be employed in a panel of markers to differentiate between various types of soft tissue tumors.

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ATRX(BSB-108),MMab

ATRX (Alpha-Thalassemia/Mental Retardation Syndrome X-linked) is a protein involved in chromatin remodeling and the maintenance of telomere stability. In neuro-oncology, the loss of nuclear ATRXx expression is a defining molecular marker for certain types of gliomas, including astrocytomas. ATRX loss istypically mutually exclusive with 1p/19gq co-deletion and is often associated with IDH mutations. ATRX IHCis an essential component of the integrated diagnostic approach for the molecular classification of adultdiffuse gliomas according to WHO guidelines.

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Annexin A1(MRQ-3),MMab

Annexin A1 is a calcium-dependent phospholipid-binding protein that mediates anti-inflammatory effects and regulates cell proliferation and apoptosis. In hematopathology, Annexin A1 is recognized as a highly sensitive and specific marker for hairy cell leukemia (HCL), effectively distinguishing it from other B-cell lymphomas such as splenic marginal zone lymphoma and chronic lymphocytic leukemia. It typically shows strong cytoplasmic and membranous staining in the neoplastic cells of HCL.

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Androgen Receptor(C1B4),MMab

The Androgen Receptor (AR) is a member of the steroid hormone receptor family that functions as aligand-dependent transcription factor. AR expression is central to the development and progression of prostate cancer and is a key marker for identifying prostatic origin in metastatic settings. Additionally, ARIHC is increasingly utilized in the characterization of certain breast cancers (e.g., apocrine differentiation)and salivary gland tumors. The presence of nuclear AR staining is a critical factor in determining thehormonal sensitivity of these malignancies.

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AMACR/p504s(C7H4),MMab

P504S, also known as α-methylacyl coenzyme A racemase (AMACR), is a peroxisomal and mitochondrial enzyme that plays a critical role in bile acid synthesis and the β-oxidation of branched-chain fatty acids. AMACR has been shown to be a highly sensitive and specific marker for prostatic adenocarcinoma. It typically exhibits a strong, granular cytoplasmic staining pattern in malignant prostatic glands, while remaining negative or weakly focal in benign glands. AMACR is frequently used in a triple-stain cocktail with basal cell markers (e.g., p63 and High Molecular Weight Cytokeratin) to increase diagnostic certainty in challenging prostate biopsies.

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SMA (C1C1), MMab

Smooth Muscle Actin (SMA) is a marker for smooth muscle cells and myoepithelial cells. It is widely expressed in the smooth muscle of blood vessel walls, visceral smooth muscle, and myoepithelial cells. SMA is a marker for smooth muscle-derived tumors and is also used to label myoepithelial cells inbreast pathology, aiding in the differential diagnosis of in situ and invasive ductal carcinoma.

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