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Cytokeratin18(DC-10),MMab

CK18 is usually co-expressed with CK8 and is present in most simple ductal and glandular epithelia. Product Specific Information: CK18 reacts with the acidic cyto keratin intermediate filament protein (45 kD) to recognize cyto keratin 18. It has been reported that CK18 is not expressed in the stratified squamous epithelium of most squamous cell carcinomas.

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Cytokeratin14 (C2D11),MMab

CK14 is a 50 kDa cytokeratin expressed in stratified epithelial cells. It can be used as a marker for squamous epithelium and breast basal cells. It is generally used in combination with other cytokeratins to distinguish whether tumor cells are derived from stratified or simple epithelial cells.

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Cytokeratin14(LL002),MMab

CK14 is a 50 kDa cyto keratin expressed in stratified epithelial cells. It can be used as a marker forsquamous epithelium and breast basal cells. It is generally used in combination with other cytokeratins to distinguish whether tumor cells are derived from stratified or simple epithelial cells.

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Cytokeratin10&13(DE-K13),MMab

Cytokeratin 10 (CK10) has a molecular weight of 56.5 kDa and mainly labels the suprabasal and granular layers of the epithelium. Cytokeratin 13 (CK13) is a marker of undifferentiated non-keratin izing stratified squamous epithelium and is highly expressed in well-differentiated tumor tissues. The expression of CK10 and CK13 often accompanies the occurrence, differentiation, and morphological changes of epithelial cells,and can be used for the study of the occurrence, development, metastasis, and prognosis of tumors derived from stratified squamous epithelium.

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Cytokeratin8/18(C7E10/C6B9), MMab

Research literature shows that CK8/18 is expressed in simple or glandular epithelium in tumors or normaltissues, such as thyroid, breast, gastrointestinal tract, and respiratory epithelium. It is expressed in adenocarcinoma and most non-keratin izing squamous cell carcinomas, but not in keratin izing squamous cell carcinomas. Therefore, this antibody is usually used in combination with CK5/6 for the differential diagnosis of adenocarcinoma and squamous cell carcinoma.

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Cytokeratin 8/18 (B22.1 & B23.1), MMab

Research literature shows that CK8/18 is expressed in simple or glandular epithelium in tumors or normaltissues, such as thyroid, breast, gastrointestinal tract, and respiratory epithelium. It is expressed in adenocarcinoma and most non-keratin izing squamous cell carcinomas, but not in keratin izing squamous cell carcinomas. Therefore, this antibody is usually used in combination with CK5/6 for the differential diagnosis of adenocarcinoma and squamous cell carcinoma.

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Cytokeratin 8(C7E10),MMab

Cytokeratin 8 (CK8) is also known as tissue polypeptide antigen (TPA). It is one of the earliest keratins expressed during embryogenesis and persists in adult tissues. CK8 and CK18 are major components of all simple epithelia but are not expressed in stratified squamous epithelium. It has been reported that CK8 is expressed in tissues of patients with adenocarcinoma and can also be detected in the serum of such patients.

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Cytokeratin 7 (C1C10),MMab

CK7 is a simple epithelial keratin mainly expressed in glandular epithelium and transitional epithelium. The combined use of CK7 and CK20 is an important tool for determining the primary site of adenocarcinoma. CK7+/CK20- suggests lung adenocarcinoma, breast cancer, etc.; CK7-/CK20+ suggests colorectal cancer.

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Cytokeratin 7(OV-TL 12/30),MMab

CK7 is a simple epithelial keratin mainly expressed in glandular epithelium and transitional epithelium. The combined use of CK7 and CK20 is an important tool for determining the primary site of adenocarcinoma. CK7+/CK20- suggests lung adenocarcinoma, breast cancer, etc.; CK7-/CK20+ suggests colorectal cancer.

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Cytokeratin 5&6 (C6H1/C1C8), MMab

CAM5.2 is a low-molecular weight cytokeratin that serves as a broad-spectrum marker for simple epithelial cells and is localized in the cytoplasm. It has been reported that CAM5.2 shows strong positivity inglandular epithelium and various adenocarcinomas, with stronger expression in glandular epithelium thanin stratified squamous epithelium. Therefore, it is one of the most commonly used markers for glandular epithelium and adenocarcinomas.

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Cytokeratin Cocktail (C7C4/C5D12),MMab

Keratins are a family of insoluble proteins with molecular weights ranging from 40 to 70 kDa. These proteins form to nofilaments in the epidermis and nearly all other epithelia and belong to the intermediate filament family. Similar to cellular differentiation, normal epidermal maturation is characterized by a series of morphological and biochemical changes progressing from the basal layer through the spinous and granular layers to the cornified layer. The AE1/AE3 antibody is a mixture of the AE1 and AE3 cones. Clone AE1 recognizes type I cytokeratins, incuding CK10CK15, CK16, and CK19, whereas clone AE3 recognizes type ll cytokeratins, including CK1, CK2, CK3, CK4, CK5, CK6, and CK8. Therefore, AE1/AE3 is a broad- spectrum anti-cytokeratin antibody. Cytokeratins of approximately 56 kDa and 65-67 kDa are specifically expressed throughout the process of terminal diferentiation of epithelial cells and can be considered molecular markers of keratinization.

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Cytokeratin Pan (AE1/AE3),MMab

Keratins are a family of insoluble proteins with molecular weights ranging from 40 to 70 kDa. These proteins form tonofilaments in the epidermis and nearly all other epithelia and belong to the intermediate filament family. Similar tocellular differentiation, normal epidermal maturation is characterized by a series of morphological and biochemical changes progressing from the basal layer through the spinous and granular layers to the cornified layer. The AE1/AE3 antibody is a mixture of the AE1 and AE3 cones. Clone AE1 recognizes type I cytokeratins, incuding CK10CK15, CK16, and CK19, whereas clone AE3 recognizes type ll cytokeratins, including CK1, CK2, CK3, CK4, CK5, CK6, and CK8. Therefore, AE1/AE3 is a broad- spectrum anti-cytokeratin antibody. Cytokeratins of approximately 56 kDa and 65-67 kDa are specifically expressed throughout the process of terminal diferentiation of epithelial cells and can be considered molecular markers of keratinization.

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