Calcitonin(polyclonal),RPab

Calcitonin (CT) is a 32-amino acid peptide synthesized by the parafollicular cells of the thyroid gland. It reduces serum calcium levels by inhibiting osteoclast-mediated bone resorption, reducing calcium reabsorption in the kidneys, and reducing intestinal calcum absorption. Its action is therefore opposite tothat of parathyroid hormone. The CT gene transcript also encodes calcitonin gene-related peptide (CGRP),which is a potent vasodilator. In thyroid parafollicular cells, 95% of the CT/CGRP is processed and translated toproduce CT. However, in nerve cells, 99% of the CT/CGRP RNA is translated into CGRP. Thyroid C-cells cangive rise to endocrine tumors, medullary thyroid carcinoma (MTC), which can be sporadic (75% of cases) or hereditary (25% of cases).

Calcitonin(polyclonal),RPab
Calcitonin(polyclonal),RPab

Intended Use

Calcitonin (CT) is a 32-amino acid peptide synthesized by the parafollicular cells of the thyroid gland. It reduces serum calcium levels by inhibiting osteoclast-mediated bone resorption, reducing calcium reabsorption in the kidneys, and reducing intestinal calcum absorption. Its action is therefore opposite tothat of parathyroid hormone. The CT gene transcript also encodes calcitonin gene-related peptide (CGRP),which is a potent vasodilator. In thyroid parafollicular cells, 95% of the CT/CGRP is processed and translated toproduce CT. However, in nerve cells, 99% of the CT/CGRP RNA is translated into CGRP. Thyroid C-cells cangive rise to endocrine tumors, medullary thyroid carcinoma (MTC), which can be sporadic (75% of cases) or hereditary (25% of cases).


Storage & Validity

Store at 2~8°C. Avoid freezing. 

Maintain temperature below room temperature during transport, ensuring it does not exceed one week.

Specifications


Product Name            Calcitonin(polyclonal),RPab
Clone            Polyclonal
Catalog No.            CCR-0190
Positive Site            Cytoplasm,
Applicable Tissue            Paraffin/frozen section
Pre-treatment            Heat retrieval
Format and Volume            Ready-to-use: 1mL, 3mL, 6mL
  • Intended Use

  • Specifications

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