SMAD4 gene is located on chromosome 18q21.1. The gene transcription has a total length of 2680 bp, contains 552 amino acids, and has a relative molecular weight of 60 kD. SMAD4 junction region is necessary for other SMADs to bind to it. SMADs are the key link that TGF-β signal enters nucleus from cytoplasm. SMAD4 plays a key role in TGF-β-mediated family signal transduction and regulating cell proliferation, differentiation, apoptosis and immune regulation.
Pancreatic cancer tissue stained with SMAD4/DPC4
CODICE |
Soluzione di lavoro |
CONCENTRATED SOLUTION |
||||
CSR-0260 |
Specifiche |
1 ml |
3 ml |
6 ml |
0.1ml |
0.2ml |
Clone: BSB-63
Fonte: Coniglio
Localizzazione: Cytoplasm/Nucleus
Pretreatment: Thermal remediation
Tessuto applicabile: Sezione paraffina