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Napsin A(C2C2), MMab

Napsin A is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

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The activation peptides of aspartic proteinases, known as pro-parts, have a specific role as inhibitors of the active site of these enzymes. They are essential for proper folding, targeting, and regulation of aspartic proteinase zymogens’ activation process. The pronapsin A gene is primarily expressed in the lung and kidney. The protein produced from this gene is predicted to be a fully functional glycosylated aspartic proteinase precursor. It contains an RGD motif (a specific amino acid sequence) and an additional 18 residues at its C-terminus.

In normal tissue, the anti-Napsin A antibody is capable of labeling type II pneumocytes in the adult lung and epithelial cells in kidney tissues. However, in abnormal tissues, Napsin A serves as a valuable marker for lung adenocarcinoma. This means that the presence of Napsin A can be indicative of lung adenocarcinoma in pathological samples.

Come mostra la figura:

Kidney tissue stained with NapsinA.