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CD31(PECAM-1)

CD31 antigen (pecam-1) is a single-stranded transmembrane glycoprotein with a molecular weight of 130 to 140kD.The CD31 molecule is expressed at junctions on the surface of platelets, monocytes, granulocytes, B cells, and endothelial cells.The CD31 molecule has an extracellular domain containing six Ig like homologous C2 subunits, which are typical cell-cell adhesion molecules.This domain mediates the adhesion between endothelial cells and cells and plays a role in maintaining the relationship between endothelial cells and the stability of monolayer endothelial cells.The CD31 molecule also has a cytoplasmic domain that is activated by the cell and becomes a potential phosphorylation site.The characteristics of CD31 antigen suggest that it is involved in the interaction between angiogenesis, thrombosis and wound healing, which is the basis of tumor growth and metastasis.