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Factor XIIIa

Factor XIIIa, also known as fibrinoligase and fibrin stabilizing factor, is the last enzyme that occurs in the coagulation cascade. It is a calcium-dependent transglutaminase or aminotransferase. Factor XIIIa is involved in the coagulation mechanism and also has the effect of stabilizing the molecular surface and membrane of cells. Factor XIIIa is detected in normal skin and inflammatory skin. XIIIa-positive cells present in the skin as a specific bone marrow dermal dendritic cell population, which is very different from Langerhans cells in the skin and shares some common features of mononuclear macrophages. In the case of benign skin lesions such as inflammatory atopic eczema and psoriasis, factor XIIIa positive cells increase in the upper part of the dermis, which is closely related to lymphocytes.